[Frontiers in Bioscience 3, d532-547, June 8, 1998]

	[Frontiers in Bioscience 3, d532-547, June 8, 1998] Reprints PubMed CAVEAT LECTOR
	NEW PERSPECTIVES ON RETINOBLASTOMA FAMILY FUNCTIONS IN DIFFERENTIATION Amy S. Yee, Heather H. Shih, and Sergei G. Tevosian The Department of Biochemistry, Tufts University School of Medicine, 136 Harrison Ave., Boston, MA 02111 Received 5/10/98 Accepted 5/29/98 TABLE OF CONTENTS 1. Abstract 2. Introduction 2.1. General Background Of The RB Family 3. Discussion: Functions In Differentiation 3.1. Summary Of Knockout Mice 3.2. Differentiation Models 3.3. Role In Cell Cycle Exit 3.3.1. E2F 3.3.2. HBP1 3.3.3. Irreversibility of cell cycle exit 3.4. Role In Apoptosis Protection 3.5 Role In Tissue-Specific Gene Expression 3.5.1 Positive Regulation 3.5.2. Negative Regulation 3.5.2.1. HBP1 3.5.2.2. p202 3.5.2.3. CHOP 3.5.2.4. p130 4.Future Perspectives 4.1 Working Model: "A Differentiation Checkpoint?" 4.1.1. The Early Phase: Cell Cycle Exit and Apoptosis Protection 4.1.2. The Late Phase: Activation of Tissue-specific Gene Expression 4.2 Future Perspectives 5. Acknowledgments 6. References 7. Entire manuscript Key words: Retinoblastoma, E2F, HBP1, p130, p107, Differentiation, Apoptosis Search OMIM (Online Mendelian Inheritance in Man) to find related articles This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms. Enter one or more search keywords: To Search all fields, leave the following boxes unchecked. To narrow your search to certain specific fields, check the boxes next to those fields' names. SeeQuery Help for other ways to search. Title: OMIM Number: Allelic Variants: Text: References: Clinical Synopsis: Gene Map Disorder: Contributors: See only records which have been changed in the past Display at most

[Frontiers in Bioscience 3, d532-547, June 8, 1998]
Reprints
PubMed
CAVEAT LECTOR

NEW PERSPECTIVES ON RETINOBLASTOMA FAMILY FUNCTIONS IN DIFFERENTIATION

Amy S. Yee, Heather H. Shih, and Sergei G. Tevosian

The Department of Biochemistry, Tufts University School of Medicine, 136 Harrison Ave., Boston, MA 02111

Received 5/10/98 Accepted 5/29/98

TABLE OF CONTENTS

1. Abstract
2. Introduction: 2.1. General Background Of The RB Family
3. Discussion: Functions In Differentiation: 3.1. Summary Of Knockout Mice
3.2. Differentiation Models
3.3. Role In Cell Cycle Exit
3.3.1. E2F
3.3.2. HBP1
3.3.3. Irreversibility of cell cycle exit

3.4. Role In Apoptosis Protection
3.5 Role In Tissue-Specific Gene Expression
3.5.1 Positive Regulation
3.5.2. Negative Regulation
3.5.2.1. HBP1
3.5.2.2. p202
3.5.2.3. CHOP
3.5.2.4. p130
4.Future Perspectives: 4.1 Working Model: "A Differentiation Checkpoint?"
4.1.1. The Early Phase: Cell Cycle Exit and Apoptosis Protection
4.1.2. The Late Phase: Activation of Tissue-specific Gene Expression
4.2 Future Perspectives

5. Acknowledgments
6. References

7. Entire manuscript

Key words: Retinoblastoma, E2F, HBP1, p130, p107, Differentiation, Apoptosis

Search OMIM (Online Mendelian Inheritance in Man) to find related articles
This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms.