[Frontiers in Bioscience 3, d746-756. July 28, 1998]

	[Frontiers in Bioscience 3, d746-756. July 28, 1998] Reprints PubMed CAVEAT LECTOR
	IgE-MEDIATED DESENSITIZATION IN HUMAN BASOPHILS AND MAST CELLS Donald MacGlashan, Jr., Sandra Lavens-Phillips, and Katsushi Miura Johns Hopkins University, Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224 Received 5/28/98 Accepted 6/8/98 TABLE OF CONTENTS 1. Abstract 2. Introduction 3. Is Secretion Self-Limiting? 4. Relationship between desensitization and release 5. Specificity of Desensitization 6. Underlying Mechanisms of Desensitization 6.1. Extracellular Negative Feedback? 6.2. Receptor loss from the cell surface? 6.3. Negative Regulation by Protein Kinase C? 6.4. Down-regulation during active secretion 6.5. Alternative Mechanisms 7. Summary 8. References 9. Entire manuscript Key words: Allergy, Immediate Hypersensitivity, Signal Transduction, Mediators, Down-Regulation Search OMIM (Online Mendelian Inheritance in Man) to find related articles This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms. Enter one or more search keywords: To Search all fields, leave the following boxes unchecked. To narrow your search to certain specific fields, check the boxes next to those fields' names. SeeQuery Help for other ways to search. Title: OMIM Number: Allelic Variants: Text: References: Clinical Synopsis: Gene Map Disorder: Contributors: See only records which have been changed in the past Display at most

[Frontiers in Bioscience 3, d746-756. July 28, 1998]
Reprints
PubMed
CAVEAT LECTOR

IgE-MEDIATED DESENSITIZATION IN HUMAN BASOPHILS AND MAST CELLS

Donald MacGlashan, Jr., Sandra Lavens-Phillips, and Katsushi Miura

Johns Hopkins University, Asthma and Allergy Center, 5501 Hopkins Bayview Circle, Baltimore, MD 21224

Received 5/28/98 Accepted 6/8/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Is Secretion Self-Limiting?
4. Relationship between desensitization and release
5. Specificity of Desensitization
6. Underlying Mechanisms of Desensitization: 6.1. Extracellular Negative Feedback?
6.2. Receptor loss from the cell surface?
6.3. Negative Regulation by Protein Kinase C?
6.4. Down-regulation during active secretion
6.5. Alternative Mechanisms
7. Summary
8. References
9. Entire manuscript

Key words: Allergy, Immediate Hypersensitivity, Signal Transduction, Mediators, Down-Regulation

Search OMIM (Online Mendelian Inheritance in Man) to find related articles
This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms.