[Frontiers in Bioscience, 3, d136-151, February 1, 1998]

	[Frontiers in Bioscience, 3, d136-151, February 1, 1998] Reprints PubMed CAVEAT LECTOR
	*MECHANISM OF ACTION OF ANTIBODY TO CAPSULAR POLYSACCHARIDE IN CRYPTOCOCCUS NEOFORMANS* INFECTION Marta Feldmesser¹and Arturo Casadevall^1,2** 1Departments of Medicine (Division of Infectious Diseases) and Microbiology and Immunology², Albert Einstein College of Medicine, Golding Building Room 701, 1300 Morris Park Ave., Bronx, NY 10461 Received 1/5/98 Accepted 1/9/98 TABLE OF CONTENTS 1. Abstract 2. Introduction 3. Overview of pathogenesis and the host immune response 4. The polysaccharide capsule 4.1. Immunomodulatory effects 4.2. Antigenic characteristics 5. The Ab response to C. neoformans 5.1. Native Ab production 5.2. Ab response to infection and vaccination 6. Polyclonal Ab 7. mAbs to the capsule of C. neoformans 7.1. Description 7.2. The role of isotype 8. Potential mechanisms of Ab action 8.1. Opsonization/phagocytosis 8.2. Enhancement of macrophage effector functions (killing) 8.3. Granulocytes as effector cells 8.4. Altered antigen presentation 8.5. Antibody-dependent cell-mediated cytotoxicity 8.6. Removal of GXM 8.7. Altered pathology 8.8. Inconsistencies 8.9. New directions: Altered cytokine expression/cellular recruitment 9. Perspective 10. Acknowledgments 11. References 12. Entire manuscript Key words: Cryptococcus neoformans, Antibody, Immunology, Monoclonal antibody, Polysaccharide, Capsule Search OMIM (Online Mendelian Inheritance in Man) to find related articles This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms. Enter one or more search keywords: To Search all fields, leave the following boxes unchecked. To narrow your search to certain specific fields, check the boxes next to those fields' names. SeeQuery Help for other ways to search. Title: OMIM Number: Allelic Variants: Text: References: Clinical Synopsis: Gene Map Disorder: Contributors: See only records which have been changed in the past Display at most

[Frontiers in Bioscience, 3, d136-151, February 1, 1998]
Reprints
PubMed
CAVEAT LECTOR

MECHANISM OF ACTION OF ANTIBODY TO CAPSULAR POLYSACCHARIDE IN CRYPTOCOCCUS NEOFORMANS INFECTION

Marta Feldmesser¹and Arturo Casadevall^1,2

1Departments of Medicine (Division of Infectious Diseases) and Microbiology and Immunology², Albert Einstein College of Medicine, Golding Building Room 701, 1300 Morris Park Ave., Bronx, NY 10461

Received 1/5/98 Accepted 1/9/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Overview of pathogenesis and the host immune response
4. The polysaccharide capsule: 4.1. Immunomodulatory effects
4.2. Antigenic characteristics
5. The Ab response to C. neoformans: 5.1. Native Ab production
5.2. Ab response to infection and vaccination
6. Polyclonal Ab
7. mAbs to the capsule of C. neoformans: 7.1. Description
7.2. The role of isotype
8. Potential mechanisms of Ab action: 8.1. Opsonization/phagocytosis
8.2. Enhancement of macrophage effector functions (killing)
8.3. Granulocytes as effector cells
8.4. Altered antigen presentation
8.5. Antibody-dependent cell-mediated cytotoxicity
8.6. Removal of GXM
8.7. Altered pathology
8.8. Inconsistencies
8.9. New directions: Altered cytokine expression/cellular recruitment
9. Perspective
10. Acknowledgments
11. References
12. Entire manuscript

Key words: Cryptococcus neoformans, Antibody, Immunology, Monoclonal antibody, Polysaccharide, Capsule

Search OMIM (Online Mendelian Inheritance in Man) to find related articles
This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms.