[Frontiers in Bioscience, 3, d468-476, April 29, 1998]
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CELLULAR ACTIVATION MECHANISMS IN SEPTIC SHOCK

Jocelyn S. Downey and Jiahuai Han

Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037

Received 4/20/98 Accepted 4/23/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Activation of MAP kinase pathways
3.1. ERK
3.2. JNK
3.3. p38 MAP kinases
3.4. Coordination of MAP kinase pathways following LPS stimulation
4. Protein kinase C
5. Src family kinases
6. NF-kB
7. Miscellaneous effects of LPS
8. Conclusions
9. Acknowledgements
10. References
11. Entire manuscript

Key words: MAP kinases, ERK kinases, JNK kinases, p38, Src kinases, Protein kinase C, NF-kB, TNF

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