CHEMOKINE RECEPTORS AND HUMAN IMMUNODEFICIENCY VIRUS INFECTION

Paul D. Bieniasz and Bryan R. Cullen

Department of Genetics and Howard Hughes Medical Institute, Duke University Medical Center, Durham, NC 27710

Received 12/15/97 Accepted 12/19/97

TABLE OF CONTENTS

1.Abstract

2. Introduction

3. HIV and SIV tropism

4. Chemokine receptors: entry cofactors for HIV and SIV

4.1 Additional coreceptors for HIV-1, HIV-2 and SIV strains.
4.2 CCR-5 is the major coreceptor used by HIV-1 in vivo

5. Mechanism of Action of Coreceptors

5.1 Envelope binding sites on coreceptors
5.2 Determinants of CCR-5 coreceptor function
5.3 Determinants of CXCR-4 coreceptor function

6. Plasticity of Envelope coreceptor interactions, implications for pathogenesis and treatment

6.1 Coreceptor targeted inhibitors of HIV entry
6.2 Changing patterns of coreceptor utilization in vivo: cause or consequence of immune suppression?

7. CD4-envelope-coreceptor complexes: what happens next?

8. References

9. Entire manuscript

Key words: HIV, SIV, Chemokines, Receptors, Viral infection, AIDS, Immunodeficiency

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