[Frontiers in Bioscience, 3, c1-7, March 1, 1998]

	[Frontiers in Bioscience, 3, c1-7, March 1, 1998] Reprints PubMed CAVEAT LECTOR
	A REGULATORY SYSTEM FOR TARGET GENE EXPRESSION Mark M. Burcin, Bert W. O´Malley and Sophia Y. Tsai Department of Cell Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA. Received 1/17/98 Accepted 2/20/98 TABLE OF CONTENTS 1. Abstract 2. Introduction 3. Regulatory Systems for target gene expression 3.1. ITPG based regulatory systems 3.2. Tetracyclin based regulatory systems 3.3. CID based regulatory system 3.4. Ecdysone based regulatory system 3.5. Estrogen-based regulatory system 3.6. A novel regulatory system based on a mutated progesterone receptor ligand binding domain. 3.6.1. Modifications of GLVP 3.6.2. Creation of ligand inducible target genes in transgenic mice 3.6.3. Inducible gene repression 3.6.4. Future applications for the regulatory system 4. Acknowledgments 5. References 6. Entire manuscript Key words: Inducible system, Gene therapy, Transgenic mice, Gene activation, Repression, RU486 Search OMIM (Online Mendelian Inheritance in Man) to find related articles This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms. Enter one or more search keywords: To Search all fields, leave the following boxes unchecked. To narrow your search to certain specific fields, check the boxes next to those fields' names. SeeQuery Help for other ways to search. Title: OMIM Number: Allelic Variants: Text: References: Clinical Synopsis: Gene Map Disorder: Contributors: See only records which have been changed in the past Display at most

[Frontiers in Bioscience, 3, c1-7, March 1, 1998]
Reprints
PubMed
CAVEAT LECTOR

A REGULATORY SYSTEM FOR TARGET GENE EXPRESSION

Mark M. Burcin, Bert W. O´Malley and Sophia Y. Tsai

Department of Cell Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.

Received 1/17/98 Accepted 2/20/98

TABLE OF CONTENTS

1. Abstract
2. Introduction
3. Regulatory Systems for target gene expression: 3.1. ITPG based regulatory systems
3.2. Tetracyclin based regulatory systems
3.3. CID based regulatory system
3.4. Ecdysone based regulatory system
3.5. Estrogen-based regulatory system
3.6. A novel regulatory system based on a mutated progesterone receptor ligand binding domain.
3.6.1. Modifications of GLVP
3.6.2. Creation of ligand inducible target genes in transgenic mice
3.6.3. Inducible gene repression
3.6.4. Future applications for the regulatory system
4. Acknowledgments
5. References
6. Entire manuscript

Key words: Inducible system, Gene therapy, Transgenic mice, Gene activation, Repression, RU486

Search OMIM (Online Mendelian Inheritance in Man) to find related articles
This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms.