THE ALZHEIMER'S PLAQUES, TANGLES AND MEMORY DEFICITS MAY HAVE A COMMON ORIGIN - PART IV: CAN CALPAIN ACT AS a-SECRETASE?

Ming Chen¹ and Hugo L. Fernandez²

^1,2 Neuroscience Research Laboratory, Medical Research Service (151), Bay Pines VA Medical Center, Bay Pines, Florida 33744, USA. ² Department of Pharmacology and Therapeutics; Department of Neurology and bDepartment of Physiology and Biophysics, University of South Florida College of Medicine, Tampa, Florida, 33612, USA

Received 11/25/98 Accepted 12/4/98

TABLE OF CONTENTS

1. Abstract

2. Introduction

3. Discussion

3.1. Calcium-dependent a-secretase
3.2. "Profile" of ß- and g-secretases
3.3. a-Secretase and calpain
3.4. Evidence in favor of calpain as a-secretase
3.5. Evidence against calpain as a-secretase
3.6. Can calpain act as a-secretase?
3.7. A theoretical model for calpain in APP processing
3.8. Experimental testing of the model
3.9. Can presenilins regulate calpain?

4. Conclusions

5. Acknowledgements

6. References

7. Entire manuscript

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