[Frontiers in Bioscience 2, d606-618, December 15, 1997]

	[Frontiers in Bioscience 2, d606-618, December 15, 1997] Reprints PubMed CAVEAT LECTOR
	HIV-1 Nef AND HOST CELL PROTEIN KINASES Kalle Saksela Institute of Medical Technology, University of Tampere, P.O. Box 607, FIN-33101, Tampere, Finland Received 11/10/97 Accepted 11/17/97 TABLE OF CONTENTS 1. Abstract 2. Phenotypic effects of Nef expression 3. Cellular partners and targets of Nef 3.1. Nef associated tyrosine kinases 3.1.1. Introduction into the Src family of tyrosine kinases 3.1.2. SH3 / Nef interaction 3.1.3. Role of the PxxP motif in vivo 3.1.4. Hck and Lyn 3.1.5. Lck and other SH3 proteins 3.2. Nef associated serine kinases 3.2.1. Nef-associated 62/72 kD kinase (NAK) 3.2.2. Other serine kinases associated with Nef 3.3. How similar are HIV and SIV Nef? 4. Concluding remarks 5. References 6. Entire manuscript Key words: Nef, HIV, SIV, AIDS, protein kinase, signal transduction, SH3 domain Search OMIM (Online Mendelian Inheritance in Man) to find related articles This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms. Enter one or more search keywords: To Search all fields, leave the following boxes unchecked. To narrow your search to certain specific fields, check the boxes next to those fields' names. SeeQuery Help for other ways to search. Title: OMIM Number: Allelic Variants: Text: References: Clinical Synopsis: Gene Map Disorder: Contributors: See only records which have been changed in the past Display at most

[Frontiers in Bioscience 2, d606-618, December 15, 1997]
Reprints
PubMed
CAVEAT LECTOR

HIV-1 Nef AND HOST CELL PROTEIN KINASES

Kalle Saksela

Institute of Medical Technology, University of Tampere, P.O. Box 607, FIN-33101, Tampere, Finland

Received 11/10/97 Accepted 11/17/97

TABLE OF CONTENTS

1. Abstract
2. Phenotypic effects of Nef expression
3. Cellular partners and targets of Nef: 3.1. Nef associated tyrosine kinases
3.1.1. Introduction into the Src family of tyrosine kinases
3.1.2. SH3 / Nef interaction
3.1.3. Role of the PxxP motif in vivo
3.1.4. Hck and Lyn
3.1.5. Lck and other SH3 proteins
3.2. Nef associated serine kinases
3.2.1. Nef-associated 62/72 kD kinase (NAK)
3.2.2. Other serine kinases associated with Nef
3.3. How similar are HIV and SIV Nef?
4. Concluding remarks
5. References
6. Entire manuscript

Key words: Nef, HIV, SIV, AIDS, protein kinase, signal transduction, SH3 domain

Search OMIM (Online Mendelian Inheritance in Man) to find related articles
This form requires a WWW Client such as Netscape, XMosaic, Lynx that supports fill-in forms.