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CROSS-TALK SIGNALS IN THE CNS: ROLE OF NEUROTROPHIC AND HORMONAL FACTORS, ADHESION MOLECULES AND INTERCELLULAR SIGNALING AGENTS IN LUTEINIZING HORMONE-RELEASING HORMONE (LHRH)-ASTROGLIAL INTERACTIVE NETWORK
Bianca Marchetti
Department of Pharmacology, Medical School, University of Catania, 95125 Catania, Laboratory of Biotech. Neuropharmacology, OASI Institute for Research and Care (IRCCS) on Mental Retardation and Brain Aging (IRCCS) Troina, (EN), Italy.
Received 8/2/96; Accepted 2/20/97; On-line 3/1/97
TABLE OF CONTENTS
- 1. Abstract
- 2. Introduction
- 2.1. Pathways involved in neuron-glia communication
- 2.2. Orchestration of neuronal migration by cell surface and extracellular matrix molecules
- 3. Growth factors and neurotrophic factors are bi-directional signaling molecules involved in neuron-glia dialogue
- 3.1. Fibroblast growth factors
- 3.2. Epidermal growth factors
- 3.3. Insulin and insulin-like growth factors
- 4. Hormones as mediators of neuron-glia plasticity
- 4.1. Sex steroids
- 4.2. Adrenal corticosteroids
- 5. The second messenger system and transcription factor network
- 6. Immune system modulation of neuron-glia interactions
- 6.1. Immunological mediators
- 7. The LHRH neuron-astroglia network of signals
- 7.1 LHRH as the primum movens in neuro-endocrine-immune control of reproduction
- 7.2. The LHRH neuronal system within the central framework of immune signaling systems
- 7.3. Growth factor and sex steroid sensitivity of the LHRH neurons
- 8. Lhrh neuron-astroglia interactions during development
- 9. Lhrh neuron-astroglia interactions in the adult brain
- 10. Characterization of astroglia influence on the LHRH neuronal system: development of an in vitro system for the study of neuron-glia interactions
- 10.1 astroglial-derived factors stimulate LHRH neuron differentiation and accelerate the maturation of LHRH secretory potential : age-dependency
- 10.2. Specificity and regional differences in astroglia modulation of GT1 neuronal differentiation
- 10.3. Peptidic nature of astroglia-derived factor
- 11. Astroglia-derived factors stimulate leucocyte proliferation
- 12. Diffusible molecules and cell-cell contacts participate in LHRH-astroglia interactions
- 12.1. Role of soluble factors
- 13. Crosstalk between astroglial-derived immune mediators and intercellular/intracellular signaling agents
- 14. The role of cell adhesion in neuron-glia interactions
- 15. Progression and competent factors exert direct neurotrophic and functional effects: presence of a synergism/cooperativity
- 16. Basic fibroblast growth factor is a candidate signal molecule that collaborates in partnership with LHRH to regulate LHRH neuron-astroglia dialogue
- 17. Summary and conclusion
- 18. References
- 19. Entire manuscript
Key words: Neuron-astroglia interactions, growth factors, neurotrophic factors, adhesion molecules, luteinizing hormone-releasing hormone (LHRH), hormones, fibroblast growth factor, cytokines, neuron migration, neurite outgrowth, neuronal survival, differentiation, astroglia proliferation
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