[Frontiers in Bioscience 2, d482-500, October 1, 1997]

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Susan M. Fischer

The University of Texas M. D. Anderson Cancer Center, Science Park-Research Division, Smithville, TX 78957

Received 9/3/97 Accepted 9/23/97


1. Abstract
2. Introduction
3.The Arachidonate Cascade
3.1Metabolic Pathways
3.2Regulation of Metabolism
3.2.1 Phospholipase A2
3.2.2 Prostaglandin synthases/Cyclooxygenases
3.2.3 Lipoxygenases
3.3 Receptors
4. Human Cancer and Experimental Animal Models
4.1 Skin Carcinogenesis
4.2 Tumors of the Colon
4.3 Tumors of the Breast
5. Mechanisms of Prostaglandin Action
5.1 Cell proliferation
5.2 Role in Apoptosis
5.3 Carcinogen Metabolism
5.4 Immune Modulation
6 Summary
7. Acknowledgments
8. References
9. Entire manuscript

Key words: Key words: arachidonic acid, prostaglandins, cancer, colon, skin, nonstroidal anti-inflammatory agents, chemoprevention

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