[Frontiers in Bioscience 1, e65-71, August 1,1996]


Brijinder S. Minhas1 and Barry A. Ripps2

1 Assisted Reprodutive Technology, The Center for Human Reproduction, 750 North Orleans, Chicago, IL 60610

2 Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Florida College of Medicine, Pensacola, FL 32503


1. E. Carlson, A. Giwercman, N. Keiding & N.E. Skakkebaek: Evidence for decreasing quality of semen during past 50 years. Brit Med J 305, 609-713 (1992)

2. K. Van Waeleghem, N. De Clercq, L. Vermeulen, F. Schoonjans & Comhair: Deterioration of sperm quality in young healthy Belgina men. Abstracts of the 10th Annual Meeting of the European Society of Human Reproduction and Embryology, Brussels, June 27-29th, Human Reprod, 9 (Suppl9) Abstract #178 (1994)

3. J. Auger, J.M. Kunstmann, F. Czyglik & P. Jouannet: Decline in semen quality among fertile men in Paris during the past 20 years. NEJM 332, 281-282 (1995)

4. R. Yanagimachi: Mammalian fertilization. Eds: Knobil E, Neill JD. The Physiology of Reproduction. Raven Press, New York, pp 189-317 (1994)

5. M.T. Zenzes, J. Belkien, I. Bordt, I. Kan, H.P. Schneider & E. Nieschlag: Cytologic investigation of human IVF failures. Fertil Steril 43,883-891 (1985)

6. S. Meizel: Molecules that initiate or help stimulate the acrosome reaction by their interaction with the mammalian sperm surface. Am J Anat 174, 285-302 (1985)

7. A.I. Yudin, W. Gottlieb & S. Meizel: Ultra-structural studies of the early events of the human sperm acrosome reaction as initiated by human follicular fluid. Gamete Res 20, 11-24 (1988)

8. B. Yee & L.M. Cummings: Modification of the sperm penetration assay using human follicular fluid to minimize false negative results. Fertil Steril 50, 123-128 (1988)

9. S.E. Ravnik, P.W. Zarutskie & C.H. Muller: Lipid transfer activity in human follicular fluid: relation to human sperm capacitation. J Androl 11, 216-226 (1990)

10. M.T. Mbizvo, L.J. Burkman & N.J. Alexander: Human follicular fluid stimulates hyperactivated motility in human sperm. Fertil Steril 54, 708-712 (1990)

11. S.S. Suarez, D.P. Wolf & S. Meizel: Induction of the acrosome reaction by human spermatozoa by a fraction of human follicular fluid. Gamete Res 14, 107 (1986)

12. J.E. Siiteri, W. Gottlieb & S. Meizel: Partial characterization of a fraction from a human follicular fluid that initiates the human sperm acrosome reaction in vitro. Gamete Res 20,25-42 (1988)

13. B.S. Minhas, B.A. Ripps, Y.P. Zhu, H.N. Kim, T.H. Burwinkel & N. Gleicher: Platelet activating factor and conception. AJRI 35, 267-271 (1996)

14. P.F.Blackmore, S.J. Beebe, D.R. Danforth & N. Alexander: Progesterone and 17 alpha-hydroxyprogesterone novel stimulators of calcium influx in human sperm. J Biol Chem 265, 1376-1380 (1990)

15. B.S.Minhas: Efficiency enhancement of manipulated male and female gametes. Sem Reprod Endocrinol 12(3), 177-183 (1994)

16. B.S.Minhas, Y.P. Zhu, H.N. Kim, B.A. Ripps & J.E. Buster: Platelet activating factor content and release from rabbit spermatozoa is stimulated by progesterone treatment. Fortieth Annual Meeting, Society for Gynecologic Investigation, Toronto, Canada, March 31-April 3, 1993; Abstract P349 (1993)

17. B.A. Ripps, Y.P. Zhu, H.N. Kim, J.E. Buster, S.A. Carson & B.S. Minhas: Progesterone treatment stimulates human spermatozoal platelet activating factor. American Fertility Society conjointly with the Canadian Fertility and Andrology Society, Montreal, Canada, October 11-14, 1993; Abstract 0159 (1993)

18. F. Snyder: Platelet activating factor and related acetylated lipids as potent biologically active cellular mediators. Am J Physiol (Cell Physiol) 259, C697-708 (1990)

19. B.S. Minhas, R. Kumar, D.D. Ricker, J.L. Robertson & M.G. Dodson: The presence of platelet activating factor-like activity in human spermatozoa. Fertil Steril 55, 372-376 (1991)

20. R. Kumar, M.J.K. Harper & D.J. Hanahan: Occurrence of platelet-activating factor in rabbit spermatozoa. Arch Biochem Biophys 360, 497-502 (1988)

21. J.E. Parks, S. Hough & C. Elrod: Platelet activating factor activity in the phospholipids of bovine spermatozoa. Biol Reprod 43, 806-811 (1990)

22. F.B. Kuzan, F.T. Geissler & W.R. Henderson: Role of platelet activating factor (PAF) in mouse in vitro fertilization. Prostaglandins 39, 61-74 (1990)

23. E.G. Bligh & W.J. Dyer: A rapid method of total lipid extraction and purification. Can J Biochem 258, 911-918 (1959)

24. P.P. Van Veldhoven & G.P. Mannaerts: Inorganic and organic phosphate measurements in the nanomolar range. Anal Biochem 161, 45-48 (1987)

25. V.R. Gujarati, R.J. Maukam & B.V. Rama Sastry: Enzymatic deacetylation and acetylation of ether phospholipids related to platelet activating factor in human semen with short and long liquefaction times. Ann N Y Acad Sci 513, 583 (1987)

26. E.D. Lentendre, P. Miron, K.D. Roberts & J. Langlais: Platelet activating factor acetylhydrolase in human seminal plasma. Fertil Steril 57, 193 (1992)

27. E. Baldi, C. Falsetti, R. Cassano & G. Forti: Stimulation of platelet activating factor synthesis in human spermatozoa. Forty-seventh Annual Meeting. Endocrine Society, San Antonio, Texas, June 24-27, 1992; Abstract 370 (1992)

28. B.S. Minhas: Efficiency enhancement of manipulated male and female gametes. Semin Reprod Endocrinol 12, 177-183 (1994)

29. D.D. Ricker, B.S. Minhas, R. Kumar, J.L. Robertson & M.G. Dodson: The effects of platelet activating factor on the motility of human spermatozoa. Fertil Steril 52, 655-658 (1989)

30. W.J.G. Hellstrom, R. Wang & S.C. Sikka: Platelet-activating factor stimulates motion parameters of cryopreserved human sperm. Fertil Steril 56, 768-770 (1991)

31. K. Jarvi, K.D. Roberts, J. Langlais & C. Gagnon: Effect of platelet-activating factor, lyso-platelet activating factor, and lysophosphatidyl-choline on sperm motion: Importance of albumin for motility stimulation. Fertil Steril 59, 1266-1275 (1993)

32. B.S. Minhas: Platelet activating factor treatment of human spermatozoa enhances fertilization potential. Am J Obstet Gynecol 168, 1314-1317 (1993)

33. M.J.Angle, C.L. Librach, R. Tom & D. McClue: The effect of platelet activating factor on sperm-mucus interaction. In Forty-fifth Annual Meeting, American Fertility Society, San Francisco, California, November 13-16, 1989; Abstract P091. (1989)

34. K..Sengoku, K. Tamate, Y. Takaoka & M. Ishikawa: Effects of platelet activating factor on human sperm function in vitro. Hum Reprod 8, 1443-1447 (1993)

35. B.S.Minhas, R. Kumar, D.D. Ricker, W.E. Roundebush, M.G. Dodson & S.J. Fortunato: The effects of platelet activating factor on mouse oocyte fertilization in vitro. Am J Obstet Gynecol 161, 1714-1717 (1989)

36. H. Shi, M. Miller, K. Miller & M.H. Kim: The effect of platelet activating factor on different phases of murine in vitro fertilization. J Assist Reprod Genet 9, 373-377 (1992)

37. K. Sengoku, M. Ishikawa. K. Tamate & T. Shimizu: Effects of platelet activating factor on mouse sperm function. J Assist Reprod Genet 9, 447-453 (1992)

38. W.E. Roudebush, B.S. Minhas, D.D. Ricker, T.V. Palmer & M.G. Dodson: Platelet activating factor enhances in vitro fertilization of rabbit oocytes. Am J Obstet Gynecol 163, 1670-1673 (1990)

39. A. Fukuda, W.E. Foudebush & S.S. Thatcher: Platelet activating factor enhances the acrosome reaction, fertilization in vitro by sperm injection and resulting embryonic development in the rabbit. Hum Reprod 9, 94-99 (1994)

40. B.S. Minhas, H.N. Kim, Y.P. Zhu, B.A. Ripps & T.H. Burwinkel: Platelet activating factor treatment of spermatozoa enhances rabbit oocyte fertilization following subzonal sperm insertion. J Asst Reprod Genet 11,308-311 (1994)

41. B.S. Minhas: Platelet activating factor treatment of spermatozoa does not impair embryonic development in vitro or in vivo. Mol Androl 3, 1-7 (1992)

42. D.J. Anderson & J.A. Hill: Cell-mediated immunity in infertility. Am J Reprod Immunol 17:22-30 (1988)

43. R.K. Naz & R. Kumar: Transforming growth factor-ß1 (TGF-ß1) enhances the expression of 2'-5' oligoadenylate synthetase in human sperm cells. J Cell Physiol 146, 156-163 (1991)

44. M. Yamamoto & K. Miyake: Successful use of interferon for male infertility. Lancet 34, 614 (1994)

45. R.K. Naz & P. Kaplan: Increased levels of interleukin-6 in seminal plasma of infertile men. J Androl 15(3), 220-227 (1994)

46. R.K.Naz, P. Kaplan: Interleukin-6 enhances the fertilizing capacity of human sperm by increasing capacitation and acrosome reaction. Androl 15, 228-233 (1994)

47. R.K.Naz, A.C. Menge & A. Sacco: Treatment with Thymosin alpha-1 increases fertilizing capacity of sperm of infertile men: a multicentertrial. Arch Androl 35, 149-154 (1995)

48. S.C. Sikka & W.J.G. Hellstrom: The application of pentoxifylline in the stimulation of sperm motion in men undergoing electroejaculation. J Androl 12, 165-170 (1991)

49. J.M. Rees, W.C.L. Ford, M.G.R. Hull: Effect of caffeine and of pentoxiylline on the motility of human spermatozoa. J Reprod Fertil 12, 147-156 (1990)

50.S.G.Perreault & B.J. Roger: Relationship between fertilizing ability and cAMP in human spermatozoa. J Androl 13, 396-401 (1992)

51. W.R. Edirisinghe, J.M. Yovich, J.M. Cummins & J.L. Yovich: Evaluation of pentoxifylline embryo toxicity using mouse IVF/ET. Fertility Society of Australia, Newcastle, Australia, p5 (1988)

52. J.M.Yovich, W.R. Edirisinghe, J.M. Cummins & J.L. Yovich: Preliminary results using pentoxifylline in a pronuclear stage tubal transfer (PROST) program for severe male factor infertility. Fertil Steril 50, 179-181 (1988)

53. J.M. Yovich, W.R. Edirisinghe, J.M. Cummins & J.L. Yovich: Influence of pentoxifylline in severe male factor infertility. Fertil Steril 53:715-722 (1990)

54. J. Tesarik, A. Thebault & J. Testart: Effect of pentoxifylline on sperm movement characteristics in normozoospermic and asthenozoospermic specimens. Hum Reprod 7, 1257-1263 (1992)

55. J.M. Cummins, S.M. Pember, A.M. Jequier, J.L. Yovich & P.E. Hartmann: A test of the human sperm acrosome reaction following ionophore challenge (ARIC): Relationship to fertility and other semen parameters. J Androl 12, 98-103, (1991)

56. J.Tesarik & C. Mendoza: Sperm treatment with pentoxifylline improves the fertilizing ability in patients with acrosome reaction insufficiency. Fertiil Steril 60, 141-148 (1993)

57. J.L. Yovich: Pentoxifylline actions and applications in assisted reproduction. Hum Reprod 8, 1786-1791 (1993)

58. R.J. Aitkin, J.S. Clarkson & T.B. Hargreave, D.S. Irvine & F.C. Wu: Analysis of the relationship between defective sperm function in the generation of reactive oxygen species in cases of oligozoospermia. J Androl 10, 214-220 (1989)

59. Sofikitis N, Toda T, Miyagawa I, Hellstrom W, Sikka S, Dickey R, Rodriguez F, Berger G, Sharhip I, Jacobs M & Mekras G: Application of ooplasmic round spermatid nuclear injections (ROSNI) for the treatment of azoospermic men in USA during 1995. Comparison of the speed of human embryonic development after ROSNI vs intracytoplasmic sperm injection (ICSI). Annual Meeting American Society for Reproductive Medicine, Seattle, WA. October 7-12, 1995. Abstract O-180 (1995)

60. R. Morris, N. Gleicher, D. Pratt, A.B. Dudkiewicz, V.C. Karande, S.G. Levrant & B.S. Minhas: Intracytoplasmic sperm injection is only beneficial when fertilization failure is due to sperm defects. Annual Meeting American Society for Reproductive Medicine, Seattle, WA. October 7-12, 1995. Abstract 0-160. (1995)

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