[Frontiers in Bioscience 1, d266-269, September 1, 1996]
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CREM: A TRANSCRIPTIONAL MASTER SWITCH DURING THE SPERMATOGENESIS DIFFERENTIATION PROGRAM

François Nantel and Paolo Sassone-Corsi

Institut de Génétique et de Biologie Moléculaire et Cellulaire, 1 rue Laurent Fries, BP 163, ILLKIRCH Cedex, C.U. de Strasbourg, France

Received 08/17/96; Accepted 08/21/96; On-line 09/01/96

6. CONCLUSIONS AND PERSPECTIVES

In the five years that followed its isolation, the transcription factor CREM has been shown to be one of the key genes implicated in the regulation of the spermatogenesis differentiation cascade. Other mutant mice with testicular phenotype similar to the one found in CREM-mutant animals have been described (19, 20). Genes encoding the apoptosis-related protein Bax (19) and the chaperone Hsp70-2 (20) are either implicated in the CREM-mediated differentiation cascade or are regulating the same or an alternative apoptosis pathway. Biochemical experiments and the development of double-knockout animals may help to address these questions.

The physiological consequences of CREM ablation have not been fully investigated especially in view of the complex expression pattern of this gene in neuroendocrine cells. Detailed analysis of endocrine and circadian alterations in the CREM-mutant mice are presently underway in our laboratory.

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