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XENOTRANSPLANTATION - STATE OF THE ART
D.K.C. Cooper, MA, PhD, MD, MS, FRCS, FACC, FACS
Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
Received 07/16/96; Accepted 08/12/96; On-line 09/01/96
TABLE OF CONTENTS
- 1. Abstract
- 2. Introduction
- 3. Concordant and discordant xenotransplantation
- 3.1. Definitions
- 3.2. Pathogenesis of graft rejection
- 3.3. Histopathology
- 3.4. Anti-Pig antibodies
- 4. Experimental methods of prolonging survival of concordant xenografts
- 5. Experimental methods of prolonging survival of discordant xenografts
- 5.1. Anti-Pig antibody depletion or inhibition
- 5.2. Complement depletion or inhibition
- 5.3. The development of tolerance to donor species by mixed chimerism
- 5.4. The genetically engineered pig
- 5.4.1. Expression of human complement-inhibiting proteins
- 5.4.2. alphaGal 'Knockout'
- 5.4.3. Competitive glycosylation
- 6. Discussion
- 7. References
- 8. Entire manuscript
Key words: xenotransplantation, hyperacute rejection, anti-pig antibodies, anti-agalactosyl antibodies, complement, mixed chimerism, genetic engineering
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